Regenerative Therapy – Polynucleotides

As we get older, our skin naturally loses some of its bounce and glow—lines start appearing, and we notice it’s not as firm or resilient as it once was.

At Athena Dermatology Clinic in Dubai, we offer a unique regenerative therapy using polynucleotides from salmon DNA to help support the skin’s own repair processes, bringing back that youthful vitality and smoothness without invasive procedures.

Polynucleotides are natural molecules, derived from DNA—specifically from salmon DNA, which has been shown to be safe and effective for skin rejuvenation because of its close resemblance to human DNA. When carefully injected into the skin, these DNA fragments work as bio-stimulants, activating fibroblasts, the cells responsible for collagen and elastin production. This process strengthens the skin’s foundation, leading to firmer, smoother skin. But polynucleotides do more than boost elasticity; they also enhance hydration, help repair tissue, and combat oxidative stress—making them especially effective for areas affected by environmental damage, aging, or scarring.

Polynucleotide therapy can be a great choice for anyone looking to refresh and rejuvenate their skin in a natural way, whether you’re dealing with:

Aging Skin: Reduce fine lines, wrinkles, and sagging while restoring elasticity.
Dry or Dull Skin: Boost hydration and radiance.
Scars or Skin Damage: Soften acne scars, sun damage, and other irregularities.
Preventative Aging: Build a “collagen bank” to maintain youthfulness over time. By injecting polynucleotides into targeted areas, the skin undergoes a multi-layered regenerative process. The polynucleotides trigger collagen and elastin production, improving skin structure, firmness, and elasticity. They also help the skin retain moisture, creating a fuller, more hydrated appearance while fighting off the effects of free radicals, which can age the skin over time. As cell turnover is supported, scars fade, and skin texture improves, resulting in a more even tone.

Most people notice improvements in skin texture and hydration within a few weeks, with optimal results showing up after 2-3 sessions. With follow-up treatments every 6-12 months, the effects can last up to a year, keeping the skin looking fresh and youthful. Polynucleotide therapy is also effective on areas like the neck, décolletage, and hands, which often show signs of aging or damage.

Since this therapy uses salmon DNA, a biocompatible material, it’s suitable for all skin types and carries minimal risk of allergic reactions. Each session contributes to long-lasting skin benefits, helping your skin build resilience and retain a youthful glow naturally.

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Our team at Athena Dermatology ensures a comfortable, personalised experience during your regenerative therapy session:
- Your dermatologist will assess your skin and discuss your goals, examining areas like elasticity, hydration, and overall texture to determine the best treatment plan.
- The treatment area is thoroughly cleaned, and a topical anaesthetic may be applied to ensure maximum comfort.
- Using fine needles, polynucleotides are gently injected into targeted areas of the skin. This process takes around 30-45 minutes, depending on the treatment area.
- After the procedure, we provide aftercare instructions to enhance the therapy's effects, including gentle skin care and sun protection guidelines.
Results and Recovery Polynucleotide therapy has minimal downtime, with most patients resuming normal activities immediately after treatment.
Temporary redness or mild swelling may occur, but this generally subsides within a few hours. You can expect gradual improvements in skin quality over the following weeks as collagen and elastin production increases. The best results are typically seen after a series of sessions spaced a few weeks apart, with continued maintenance sessions enhancing long-term effects.
To achieve the best results and minimise any potential side effects, follow these guidelines before your polynucleotide therapy session:
- Avoid medications like aspirin, ibuprofen, or any other blood thinners 5-7 days before treatment unless otherwise directed by your doctor. This reduces the risk of bruising.
- Refrain from consuming alcohol and excessive caffeine for 24 hours before your appointment, as these can increase the risk of bruising and dehydration.
- Discontinue using retinoids, AHAs, BHAs, and other active ingredients on the treatment area for at least 3-5 days before your appointment. This will help minimise skin sensitivity.
- Drink plenty of water in the days before your treatment. Well-hydrated skin responds better and heals faster.
- Before your session, minimise sun exposure and avoid tanning or sunburns on the treatment area, as irritated skin can be more sensitive during the procedure.
Taking care of your skin after the procedure will help maximise the results and support the healing process:
- Gently cleanse and moisturise the treated area twice daily. Hydration is essential to support the effects of the polynucleotides and aid in skin recovery.
- Use a broad-spectrum sunscreen (SPF 30 or higher) daily on the treated areas. Avoid direct sun exposure and tanning beds for at least a week after the procedure to prevent hyperpigmentation and protect your results.
- For 48 hours after treatment, refrain from intense exercise, saunas, hot baths, or steam rooms, as excessive heat and sweating can increase swelling and delay healing.
- For 24 hours, avoid makeup on the treated area to allow the skin to breathe. To prevent irritation, avoid active skincare ingredients (like retinoids, AHAs, or BHAs) for a few days.
- Drink plenty of water to support your skin’s hydration and healing process.
- Mild redness or swelling is normal and should subside within a few hours. Contact the clinic if you experience unusual symptoms, such as prolonged redness or discomfort.

FAQ about Regenerative Therapy - Polynucleotides

Absolutely. This therapy is safe for all skin types, as polynucleotides are naturally compatible with the body and have minimal risk of side effects.
Results develop gradually as the skin’s collagen production increases. Most patients notice improved skin texture and hydration within a few weeks, with optimal results becoming visible after 2-3 sessions.
With a full treatment course, results can last up to 12 months. Regular maintenance sessions every 6-12 months can help extend these benefits and maintain the skin’s youthful appearance.
Yes, this therapy is effective on multiple body areas, including the neck, décolletage, and hands, where signs of ageing or skin damage may appear.
While fillers add volume to specific areas, polynucleotide therapy stimulates the skin’s natural regeneration processes. This makes it ideal for improving skin texture, elasticity, and hydration rather than just adding volume.
Yes, polynucleotide therapy is generally safe for all skin types, including sensitive skin. The biocompatibility of polynucleotides reduces the risk of adverse reactions, and our dermatologists tailor the treatment to suit each patient’s unique skin needs.
Both treatments aim to stimulate collagen and support skin regeneration, but polynucleotides specifically focus on boosting collagen, elastin, and hydration at a cellular level. PRP uses your body’s platelets, while polynucleotide therapy introduces external DNA fragments that are especially effective for deep hydration and antioxidant effects.
Polynucleotide therapy mainly targets hydration, elasticity, and collagen production. While it doesn’t directly lighten dark spots, improved skin health and regeneration can help brighten skin tone, making it a complementary treatment to other pigmentation-focused therapies.
Yes, polynucleotide therapy can be safely combined with treatments like microneedling, PRP, and chemical peels for enhanced anti-ageing effects. Combining therapies can create a more comprehensive approach to skin rejuvenation, but it’s best to consult your dermatologist to design a personalised treatment plan.
Directly after treatment, you may experience mild redness or slight swelling, which typically subsides within a few hours. Once this fades, your skin may look slightly plumper and more hydrated, but the full regenerative effects will appear gradually over the next few weeks.
Polynucleotides promote collagen synthesis, which helps to improve skin texture and smooth out irregularities caused by acne scars. While not a complete solution, this therapy can soften the appearance of scars and improve overall skin tone and texture.
Polynucleotide therapy can help slow down the formation of new wrinkles by stimulating ongoing collagen production and improving skin hydration, acting as a preventative anti-ageing measure.
Yes, maintaining a healthy lifestyle supports your skin’s natural regenerative process. Staying hydrated, eating a balanced diet rich in antioxidants, and avoiding smoking and excessive sun exposure can all help prolong and enhance your results.

Refresh, Restore, and Rejuvenate with confidence using the best polynucleotide regenerative therapy in Dubai

To book your consultation, call us at 042505081 or fill out our online contact form. Rejuvenate your skin naturally with science-backed therapy that brings out your skin’s best potential.